主要研究方向
1.小RNA降解酶translin/trax复合体在多巴胺通路及精神疾病中的功能研究
2．小RNA降解酶translin/trax复合体在脂肪组织发育及代谢病中的功能研究
工作经历
2021年12月至今 特聘副研究员 天津工业大学生命科学学院
2018年8月—2021年1月，Research Associate， Department of Neuroscience， Johns Hopkins School of Medicine，USA
2011年9月-2018年7月，postdoc fellow，Department of Neuroscience，Johns Hopkins School of Medicine，USA
教育经历
2004年9月-2011年7月 中科院遗传与发育生物学研究所 细胞生物学博士
2000年9月-2004年7月 南开大学生命科学学院 生物技术学士
发表论文
1. Fu X, Shah AP, Keighron J, Mou T, Ladenheim B, Alt J, Fukudome D, Niwa M, Tamashiro KL, Tanda G, Sawa A, Cadet J, Rais R, Baraban JM. Elevated body fat increases amphetamine accumulation in brain: evidence from genetic and diet-induced forms of adiposity. TRANSL PSYCHIAT. 2021 Aug 14;11(1):427.
2. Tuday E, Nakano M, Akiyoshi K, Fu X, Shah AP, Yamaguchi A, Steenbergen C, Santhanam L, An SS, Berkowitz D, Baraban JM, Das S. Degradation of premature-miR-181b by the translin/trax RNase increases vascular smooth muscle cell stiffness. Hypertension. 2021 2021 Sep;78(3):831-839.
3. Fu X, Shah AP, Li Z, Li M, Tamashiro KL, Baraban JM. Genetic inactivation of the translin/trax microRNA-degrading enzyme phenocopies the robust adiposity induced by Translin (Tsn) deletion. Mol Metab. 2020 Oct;40:101013.
4. Shah AP#1, Johnson MD#1, Fu X#1, Boersma GJ, Shah M, Wolfgang MJ, Tamashiro KL, Baraban JM. Deletion of translin (Tsn) induces robust adiposity and hepatic steatosis without impairing glucose tolerance. Int J Obes (Lond). 2020 Jan;44(1):254-266. （共同一作）
5. Tuday E, Nomura Y, Ruhela D, Nakano M, Fu X, Shah A, Roman B, Yamaguchi A, An SS, Steenbergen C, Baraban JM, Berkowitz DE, Das S. Deletion of the microRNA-degrading nuclease, translin/trax, prevents pathogenic vascular stiffness. Am J Physiol Heart Circ Physiol. 2019 Nov 1;317(5):H1116-H1124.
6. Chern Y, Chien T, Fu X, Shah AP, Abel T, Baraban JM. Trax: A versatile signaling protein plays key roles in synaptic plasticity and DNA repair. Neurobiol Learn Mem. 2019 Mar;159:46-51.
7. Baraban JM, Shah A, Fu X. Multiple Pathways Mediate MicroRNA Degradation: Focus on the Translin/Trax RNase Complex. Adv Pharmacol. 2018;82:1-20.
8. Park AJ, Havekes R#2, Fu X#2, Hansen R#2, Tudor JC, Peixoto L, Li Z, Wu YC, Poplawski SG, Baraban JM, Abel T. Learning induces the translin/trax RNase complex to express activin receptors for persistent memory. Elife. 2017 Sep 20;6:e27872.（共同二作）
9. Xu C, Fu X, Zhu S, Liu JJ. Retrolinkin recruits the WAVE1 protein complex to facilitate BDNF-induced TrkB endocytosis and dendrite outgrowth. Mol Biol Cell. 2016 Nov 1;27(21):3342-3356.
10. Fu X, Shah A, Baraban JM. Rapid reversal of translational silencing: Emerging role of microRNA degradation pathways in neuronal plasticity. Neurobiol Learn Mem. 2016 Sep;133:225-232.
11. Asada K, Canestrari E, Fu X, Li Z, Makowski E, Wu YC, Mito JK, Kirsch DG, Baraban J, Paroo Z. Rescuing dicer defects via inhibition of an anti-dicing nuclease. Cell Rep. 2014 Nov 20;9(4):1471-81.
12. Fu X, Yang Y, Xu C, Niu Y, Chen T, Zhou Q, Liu JJ. Retrolinkin cooperates with endophilin A1 to mediate BDNF-TrkB early endocytic trafficking and signaling from early endosomes. Mol Biol Cell. 2011 Oct;22(19):3684-98.