吴依璠

发布者：卢钧胜发布时间：2025-06-09浏览次数：5217



吴依璠

博士、副教授、硕导

研究方向一：心血管生物材料与组织工程

研究方向二：生物医学电子与医疗仪器


生日：1992-02-19

政治面貌：党员

邮箱：wuyifan@tiangong.edu.cn

办公地点：天津工业大学生命科学学院3C310

导师类型：学术型硕士生导师、专业型硕士生导师

职务：生物医学工程系副主任、支部书记



教育及工作背景

2019.11 - 至今天津工业大学生命科学学院生物医学工程系专任教师

2020.12 - 2023.12南开大学药物化学生物学国家重点实验室博士后

2014.09 - 2019.06 南开大学生命科学学院生物化学与分子生物学专业博士

2017.10 - 2018.10 伦敦大学国王学院心血管系，联合培养博士

2010.09 - 2014.06 山东大学生命科学学院生物技术专业学士



主讲课程

《生命科学导论》、《生物医用材料》、《医学与工程伦理》



科研项目

  1. 国家自然科学基金青年基金，CRISPR/Cas9系统原位基因编辑干细胞促进小口径人工血管组织再生研究，主持

  2. 中国博士后科学基金面上项目，原位基因编辑结合仿生结构协同促进病理环境下小口径人工血管的功能再生，主持

  3. 天津市自然科学基金青年项目，原位干细胞重编程促进病理环境下人工血管的组织再生研究，主持

  4. 中国纺织工业联合会科技指导性项目，基因复合物修饰的聚己内酯静电纺丝人工血管开发研究，主持

  5. 教育部产学合作协同育人项目，“人工智能+”生物医学工程专业高质量人才培养体系建设，主持

  6. 天津市自然科学基金重点项目，光学和超声双模态神经重症脑血流监测关键技术研究，参与

  7. 企业委托课题2项，重点实验室开放课题1项，主持



代表性论文

  1. Wu Yifan, Wang Xixi, Song Lili, Zhao Zhe, Xia Ying, Tang Kai, Wang Huiquan, Liu Jing, Wang Zhihong*. Tuning macrophage phenotype for enhancing patency rate and tissue regeneration of vascular grafts. Acta Biomaterialia. 2025, 198: 245-256.（中科院1区，Top，IF = 9.4）

  2. Wu Yifan, Xia Ying, Song Lili, Wang Xixi, Zhang Jun, Liu Jing, Wang Zhihong*. Implantation of Tissue-Engineered Vascular Graft in Mouse Carotid Artery via Cuff Technique. Journal of Visualized Experiments. 2025, 219.

  3. Han Guang, Li De, Yuan Jixin, Lu Jie, Zhang Jun, Wang Huiquan, Chen Ruijuan*, Wu Yifan*. A comparative study between laser speckle contrast imaging in transmission and reflection modes by adaptive window space direction contrast algorithm. Biomedical Signal Processing and Control. 2025, 100: 107091.（中科院2区，IF = 4.9）

  4. Wu Yifan, Zou Junwu, Tang Kai, Xia Ying, Wang Xixi, Song Lili, Wang Jinhai, Wang Kai*, Wang Zhihong*. From electricity to vitality: the emerging use of piezoelectric materials in tissue regeneration. Burns & Trauma, 2024, 12, tkae013.（中科院1区，IF = 6.3）

  5. Wu Yifan#, Song Lili, Muhammad Shafiq#, Hiroyuki Ijima, Soo Hyun Kim, Wei Ran, Kong Deling, Mo Xiumei*, Wang Kai*. Peptides-tethered vascular grafts enable blood vessel regeneration via endogenous cell recruitment and neovascularization. Composites Part B. 2023, 252: 110504.（中科院1区，Top，IF = 11.322）

  6. Chen Ruijuan, Li Dandan, Zhao Songsong, Zhang Yuanxin, Wang Huiquan, Wu Yifan*. Simulation of dynamic monitoring for intracerebral hemorrhage based on magnetic induction phase shift technology. Review of Scientific Instruments. 2023, 94, 064101.

  7. 吴依璠，智登科，Adam C. Midgley, 赵强，孔德领*，王恺* . 人工血管组织再生的细胞来源. 中国科学：生命科学,2019,49:1100.

  8. Shirin Issa Bhaloo#, Wu Yifan#, Alexandra Le Bras, Yu Baoqi, Gu Wenduo, Xie Yao, Deng Jiacheng, Wang Zhihong, Zhang Zhongyi, Kong Deling, Hu Yanhua, Qu Aijuan, Zhao Qiang*, Xu Qingbo*. Binding of Dickkopf-3 to CXCR7 Enhances Vascular Progenitor Cell Migration and Degradable Graft Regeneration. Circulation Research. 2018, 123(4): 451-466.（中科院1区，Top，IF = 23.213）

  9. Zhu Meifeng#, Wu Yifan#, Li Wen, Dong Xianhao, Chang Hong, Wang Kai, Wu Pingli, Zhang Jun, Fan Guanwei, Wang Lianyong, Liu Jianfeng, Wang Hongjun*, Kong Deling*. Biodegradable and elastomeric vascular grafts enable vascular remodeling. Biomaterials. 2018, 183: 306-318.（中科院1区，Top，IF = 15.304）

  10. Wu Yifan, Qin Yibo, Wang Zhihong*, Wang Jianing, Zhang Chuangnian, Li Chen, Kong Deling*. The regeneration of macro-porous electrospun poly(ε-caprolactone) vascular graft during long-term in situ implantation. Journal of Biomedical Materials Research Part B. 2017, 106(4), 1618-1627.

  11. Wang Zhihong#, Wu Yifan#, Wang Jianing, Zhang Chuangnian, Yan Hongyu, Zhu Meifeng, Wang Kai*, Li Chen, Xu Qingbo, Kong Deling*. The effect of resveratrol on modulation of endothelial cells and macrophages for rapid vascular regeneration from electrospunpoly(ε-caprolactone) scaffolds. ACS Applied Materials & Interfaces. 2017, 9(23):19541-19551.

  12. Wei Yongzhen#, Wu Yifan#, Zhao Runxia, Zhang Kaiyue, Adam C. Midgley, Kong Deling, Li Zongjin*, Zhao Qiang*. MSC-derived sEVs enhance patency and inhibit calcification of synthetic vascular grafts by immunomodulation in a rat model of hyperlipidemia. Biomaterials. 2019, 204: 13-24.（中科院1区，Top，IF = 15.304）

  13. Liu Jing#, Qin Yibo#, Wu Yifan, Sun Zhiting, Li Binhan, Jing Huimin, Zhang Chuangnian, Li Chen, Leng Xigang, Wang Zhihong*, Kong Deling*. Biomaterials Science. 2019. 7(3): 914-925.

  14. Qin Kang, Wu Yifan, Pan Yiwa, Wang Kai*, Kong Deling, Zhao Qiang*. Journal of Visualized Experiments. 2018, 136.

  15. Wang Juan#, Liu Lumei#, Wu Yifan, Manfred F Maitz, Wang Zhihong, Youngmi Koo, Ansha Zhao, Jagannathan Sankar, Kong Deling, Huang Nan*, Yeoheung Yun*. Acta biomaterialia. 2017, 50: 546-555.

  16. Wang Zhihong#, Zheng Wenting#, Wu Yifan, Wang Jianing, Zhang Xiuyuan, Wang Kai, Zhao Qiang, Kong Deling, Ke Tingyu, Li Chen. Biomaterials Science. 2016, 4: 1485-1492.



授权发明专利

王志红，孔德领，吴依璠，可控释放白藜芦醇和/或白藜芦醇衍生物的载体及其制备方法与应用，2020.1.31，中国，ZL 2016 1 1033078.9


指导学生获奖情况

  1. 指导学生获“挑战杯”大学生创业计划项目天津市金奖、全国银奖;

  2. 指导学生获全国大学生生物医学工程竞赛、全国大学生生命科学竞赛、“互联网+”大学生创新创业大赛三等奖;

  3. 指导大学生创新创业项目国家级2项，市级2项。